A new study demonstrates that gender dysphoria in individuals with coexisting psychotic disorders can be adequately diagnosed and safely treated with gender affirming psychological, endocrine, and surgical therapies. The study is published in LGBT Health, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the LGBT Health website until May 3, 2017. In this novel and important report, Julia Meijer, MD, PhD, Guus Eeckhout, MD, Roy van Vlerken, MD, and Annelou de Vries, MD, PhD, VU University Medical Center, Amsterdam, The Netherlands, describe a small series of case studies involving transgender men and women ages 29-57 years diagnosed with gender dysphoria and schizophrenia-related disorders who underwent gender affirmative treatment with a minimum follow-up of 3 years.