Placentas from 15 consenting healthy women were donated to the study following the birth of their children at The Royal London Hospital. Pollution exposure was determined in 13 of the women, all of whom had exposure above the annual mean WHO limit for particulate matter. The cells in the placentas were analysed using a range of techniques including light and electron microscopy, x-rays and magnetic analyses.
Black particles that closely resembled particulate matter from pollution were found in placental cells from all fifteen women and these appeared in an average of 1 per cent of the cells which were analysed.
The majority of particles found in the placental cells were carbon-based, but researchers also found trace amounts of metals including silica, phosphorus, calcium, iron and chromium, and more rarely, titanium, cobalt, zinc and cerium.
Analysis of these nanoparticles strongly suggests that they predominantly originated from traffic-related sources. Many of these metals are associated with fossil fuel combustion, arising from fuel and oil additives, and vehicle brake-wear.
Dr Lisa Miyashita from Queen Mary University of London said: “We have thought for a while that maternal inhalation could potentially result in pollution particles travelling to the placenta once inhaled. However, there are many defence mechanisms in the lung that prevent foreign particles from travelling elsewhere, so it was surprising to identify these particles in the placental cells from all 15 of our participants.”
Fiona Miller Smith, Chief Executive of Barts Charity said: “This is an incredibly important study and immensely relevant to mums-to-be in our local community, indeed in any urban community anywhere in the world.
“In the current climate it can be hard to see beyond COVID and so we are particularly proud to have funded this vital work and truly hope that it will lead to greater awareness of the risks of pollution to the unborn child.”
The study involved researchers from University of Lancaster, Barts Health NHS Trust, University of Manchester, Central Manchester University Hospital NHS Foundation Trust, King's College London, University of Birmingham, University of Oxford and University of Leeds.
