Pre-menopausal women with the most common type of advanced breast cancer are usually excluded from medical research unnecessarily, according to an expert panel at the Advanced Breast Cancer Fourth International Consensus Conference (ABC 4). In new guidelines for treating advanced breast cancer agreed today (Saturday), the panel said that the majority of clinical trials for hormone-dependent advanced breast cancer either explicitly exclude pre-menopausal women, or deter them by means of unnecessarily restrictive inclusion criteria. The panel has called for future trials to be designed to enable both pre- and post-menopausal women to be enrolled. Chair of the ABC 4 conference, Professor Fatima Cardoso, Director of the Breast Unit of the Champalimaud Cancer Centre in Lisbon, Portugal, said: “At present, not only are younger women denied the opportunity to take part in clinical trials, but also clinicians lack the evidence on how best to treat these patients who have advanced breast cancer with limited therapies available.”

 An investigation coordinated by researchers at Ca' Foscari University of Venice gathered the insights of about 200 international experts. Italian Minister of Health Beatrice Lorenzin will present the results tomorrow in Milan . Decisions that will be taken at the G7 Ministerial Meeting on Health that will be open by Minister Beatrice Lorenzin tomorrow in Milan have followed an intense dialogue with the international scientific community on the most efficient strategies to be adopted to deal with the impact of climate changes on health on a global scale in the near future. Since January 2017 and the beginning of preparatory works, the Italian Ministry of Health welcomed a team of researchers from Ca’ Foscari University of Venice coordinated by professor Stefano Campostrini, in collaboration with Foresight, an interdepartmental project of the Consiglio Nazionale delle Ricerche (Cnr). Together they designed a questionnaire that was sent out to experts around the world, especially to G7 countries and countries that are particularly vulnerable to the impact of climate change. Reducing emissions and reinforcing surveillance systems were identified by scientists as two of the most urgent global measures to be adopted.

Pheel (Physiology Emotion Experience Lab) è un nuovo laboratorio del Politecnico di Milano che unisce le competenze multidisciplinari dei Dipartimenti di Elettronica, Informazione e Bioingegneria (DEIB), Design e Ingegneria Gestionale. Il laboratorio muove dalla constatazione che gli aspetti razionali alla base delle decisioni degli individui, generalmente misurate con indagini demoscopiche e questionari di opinione, stanno diminuendo il loro peso nei processi decisionali, che diventano sempre più determinati da impatti viscerali, emotivi e di relazione sociale. Attraverso l’analisi biometrica e la valutazione esperta, Pheel misura e studia come gli individui reagiscono, valutano e filtrano stimoli di comunicazione, prodotti, servizi o esperienze di interazione con la marca. Nel laboratorio vengono infatti analizzati i segnali biologici e fisiologici degli individui e valutati i loro comportamenti in risposta a specifici stimoli (prodotti/servizi/esperienze, interfacce, messaggi pubblicitari, contenuti editoriali, messaggi di comunicazione non pubblicitaria, interazione sociale, ecc.). Le strumentazioni utilizzate nelle ricerche non sono invasive e sono state testate e verificate su diverse tipologie di soggetti, compresi bambini e persone in condizioni di fragilità.

Un team internazionale di ricercatori ha appena descritto una nuova specie di grande scimmia, l’orango di Tapanuli (Pongo tapanuliensis), che vive unicamente nelle foreste di montagna nel nord dell’isola di Sumatra, in Indonesia.
Con non più di 800 individui, questa specie è la grande scimmia più minacciata di tutto il pianeta. Un team internazionale di scienziati ha descritto la nuova specie nella rivista Current Biology, basandosi su caratteristiche morfologiche e approfondite analisi genomiche. La nuova specie, chiama orango di Tapanuli (Pongo tapanuliensis), è endemico della regione di Tapanuli nel Nord di Sumatra e vive esclusivamente in circa 1.100 chilometri quadrati di foresta di montagna nell’area di Batang Toru.
"Nonostante i quasi 50 anni di ricerca sugli oranghi a Sumatra, la popolazione di Batang Toru è stata scoperta scientificamente solo nel 1997, durante una serie di indagini sul campo", afferma il prof. Erik Meijaard, che ha effettuato la prima ricerca sulle popolazioni di orango a sud del lago Toba.

The mean maximum annual temperatures increase gradually from the north of the Red Sea to its south. Reproduced with permission from reference  2017 Nature Publishing Group

The world’s warmest sea is heating up faster than the global average, which could challenge the ability of the Red Sea’s organisms to cope. “The global rate of ocean warming has many consequences for life on this planet. Now we are learning that the Red Sea is warming even faster than the global average,” says KAUST PhD student of marine science, Veronica Chaidez. The analyses, conducted by a multidisciplinary team spanning all three divisions at KAUST, provide vital data that could help predict the future of the Red Sea’s marine biodiversity when supplemented by evidence to be gathered on the thermal limits of local organisms. Analyses of satellite sensing data from 1982 to 2015 show that the Red Sea’s maximum surface temperatures have increased at a rate of 0.17 ± 0.07°C per decade, exceeding the global ocean warming rate of 0.11°C per decade. Maximum sea-surface temperatures were found to increase from north to south along the Red Sea basin, with the coolest temperatures located in the gulfs of Suez and Aqaba in the far North. These two gulfs, however, are showing the highest rates of change compared to the rest of the basin at 0.40–0.45°C per decade; four times faster than the mean global ocean warming rate. 

Towards an early diagnosis through hearing capacity

Almost 10% of the world population suffers dyslexia. Establishing an early diagnosis would allow the development of training programs to palliate this disorder. We now may be nearer to reaching this goal thanks to a study carried out by the Basque Centre on Cognition, Brain and Language (BCBL), associating auditory processing in children to their reading skills. The results offer a new approach for detecting the risk before the children learn to read. Difficulty recognising words, decoding and writing problems, limitation of reading comprehension... These are the main consequences of dyslexia, a cognitive disorder of neurological origin in which a late diagnosis is the main handicap. A study led by investigators of the Basque Centre on Cognition, Brain and Language (BCBL) has demonstrated a relationship between the capacity of children to learn how to read and their hearing ability. This breakthrough, published in Frontiers in Psychology, casts light upon the detection of the disorder and could help establish the risk of dyslexia from an early stage, as well as develop training programmes to palliate reading limitations on a preemptive basis.

A Montreal Clinical Research Institute discovery sheds light on osteocalcin, a hormone produced by our bones that affects how we metabolize sugar and fat. Your skeleton is much more than the structure supporting your muscles and other tissues. It produces hormones, too. And Mathieu Ferron knows a lot about it. The researcher at the Montreal Clinical Research Institute (IRCM) and professor at Université de Montréal’s Faculty of Medicine has spent the last decade studying a hormone called osteocalcin. Produced by our bones, osteocalcin affects how we metabolize sugar and fat. In a recent paper in The Journal of Clinical Investigation, Ferron’s team unveiled a new piece of the puzzle that explains how osteocalcin works. The discovery may someday open the door to new ways of preventing type 2 diabetes and obesity.

There is a difference between male and female physics faculty salaries and the culture of physics is partly to blame, according to an article that is available for free this month from Physics Today, the world's most influential and closely followed magazine devoted to physics and the physical sciences community. The article, "Salaries for female physics faculty trail those for male colleagues," identifies key factors influencing the gender pay gap and offers potential solutions that include changes in the culture in physics departments. The article is available at https://doi.org/10.1063/PT.3.3760. Staff writer Toni Feder combined data from a 2010 report, “Gender Differences at Critical Transitions in the Careers of Science, Engineering, and Mathematics Faculty” (https://www.nap.edu/catalog/12062/gender-differences-at-critical-transitions-in-the-careers-of-science-engineering-and-mathematics-faculty), from the National Academies of Sciences, Engineering, and Medicine that looked at hundreds of institutions with unpublished data from the American Institute of Physics (AIP) Statistical Research Center (SRC). AIP is the publisher of Physics Today.

 When overweight adults exchange refined grain products – such as white bread and pasta – with whole grain varieties, they eat less, they lose weight and the amount of inflammation in their bodies decreases. These are some of the findings of a large Danish study headed by the National Food Institute, Technical University of Denmark. The study supports the scientific basis for the Danish dietary recommendation to choose whole grains. The beneficial effect of eating whole grain instead of refined grain products is well documented. Epidemiological studies have shown that whole grain consumption decreases the risk of development of e.g. cardiovascular diseases. In the most comprehensive study to date of its kind, researchers have studied the effect of exchanging refined grain products in the diet – such as white bread and pasta – with whole grain varieties. The National Food Institute headed the study, which was carried out in close cooperation with the Department of Nutrition, Exercise and Sports at the University of Copenhagen and DTU Bioinformatics. A large number of other researchers from Danish universities and hospitals additionally contributed to the study.

 Regional data also suggest some teens who abuse cannabis outgrow habit in adulthood

About a quarter of adults whose marijuana use is problematic in early adulthood have anxiety disorders in childhood and late adolescence, reports a study published in the November 2017 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). The findings also shed light on an estimated 4 percent of adults who endured childhood maltreatment and peer bullying without resorting to chronic marijuana abuse, only to develop problems with the drug between the ages of 26 and 30. "Given that more states may be moving towards legalization of cannabis for medicinal and recreational purposes, this study raises attention about what we anticipate will be the fastest growing demographic of users-adults," said lead author Sherika Hill, PhD, an adjunct faculty associate at the Duke University School of Medicine. "A lot of current interventions and policies in the US are aimed at early adolescent users. We have to start thinking about how we are going to address problematic use that may arise in a growing population of older users."