Some marine species more vulnerable to climate change than others
Certain marine species will fare much worse than others as they become more vulnerable to the effects of climate change, a new UBC study has found. After analyzing the biological characteristics of 1,074 marine fish and shellfish, the study identified 294 species that are most at-risk due to climate change by 2050. Species most at-risk include the Eastern Australian salmon, yellowbar angelfish, toli shad, sohal surgeonfish and spotted grouper. “We hope that this study will highlight the marine species that are most in need of management and conservation actions under climate change,” said William Cheung, associate professor in the Institute for the Oceans and Fisheries and director of science for the Nippon Foundation – UBC Nereus Program.
Three or More Cups of Coffee Daily Halves Mortality Risk in Patients with Both HIV and HCV
Novel five-year study highlights importance of behaviors such as coffee drinking and not smoking on health and survival of HIV-infected patients, report investigators in the Journal of Hepatology. Patients infected by both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) are at specific risk of end-stage liver disease and greater risk of cardiovascular diseases and cancer. In addition, HIV infection accelerates the progression of chronic hepatitis C to fibrosis and development of cirrhosis and end-stage liver disease. In these HIV-HCV co-infected patients, drinking at least three cups of coffee each day halved the risk of all-cause mortality according to a new study published in the Journal of Hepatology. This study is the first to investigate the relationship between coffee consumption and the risk of all-cause mortality in HIV-HCV co-infected patients. “This is a very exciting time for HCV research as a cure that can eradicate the virus is now available for all patients,” explained lead investigator Dominique Salmon-Céron, MD, PhD, of the Service des Maladies Infectieuses et Tropicales, Hôpital Cochin, and Université Paris Descartes, Paris, France. “However, even when cured of HCV, patients co-infected with HIV have a higher risk of death with respect to the general population, due to an accelerated aging process that may result from cancer, complications related to diabetes and to liver disease, and from cardiovascular events.”
Brain damage in fish affected by plastic nanoparticles
A new study from Lund University in Sweden shows that plastic particles in water may end up inside fish brains. The plastic can cause brain damage, which is the likely cause of behavioural disorders observed in the fish. Calculations have shown that 10 per cent of all plastic produced around the world ultimately ends up in the oceans. As a result, a large majority of global marine debris is in fact plastic waste. Human production of plastics is a well-known environmental concern, but few studies have studied the effects of tiny plastic particles, known as nanoplastic particles. “Our study is the first to show that nanosized plastic particles can accumulate in fish brains”, says Tommy Cedervall, a chemistry researcher at Lund University. The Lund University researchers studied how nanoplastics may be transported through different organisms in the aquatic ecosystem, i.e. via algae and animal plankton to larger fish. Tiny plastic particles in the water are eaten by animal plankton, which in turn are eaten by fish.
New treatment for chronic throat irritation and globus sensation in the gullet
For the first time in the world, the new radiofrequency ablation technique has been successfully used in severe cases
Chronic throat irritation, a permanent globus sensation, a sore or dry sensation in the throat are common symptoms, which are often trivialised and wrongly attributed to gastro-oesophageal reflux disease. However, these are also the characteristic symptoms of patients suffering from displaced gastric mucosa in the oesophagus (ectopic mucosa). The recent study conducted by researchers from MedUni Vienna and Vienna General Hospital has now brought a break-through in the treatment of patients with this condition. For the first time in the world, the new radiofrequency ablation technique has been successfully used in severe cases.
The symptoms are caused by a section of misplaced gastric mucosa, which is found in the oesophagus rather than as normal in the stomach during gastroscopy in nearly 10 – 15% of people and this results in chronic damage to the larynx due to the production of acid and mucous. Up until now there has been no safe and effective option for treating pronounced forms of this condition. The first application of radiofrequency ablation brings about a significant improvement in the condition. The study has now been published in the leading journal "Digestive Endoscopy".
Diabetes medicine reduces Parkinson’s risk
Charalampos Tzoulis (right) and his colleagues, Kristoffer Haugarvoll (left) and Brage Brakedal, hope they are one step closer to a cure for Parkinson´s disease. Photo: Kim E. Andreassen
A Norwegian study shows that the taking of diabetes medicine reduces the risk of getting Parkinson´s disease.
Researchers at the Department of Clinical Medicine at the University of Bergen (UiB) have discovered that medical treatment against diabetes reduces the risk of getting Parkinson´s disease by 35 per cent. “We have made an important discovery, which takes us a step further towards solving the Parkinson´s riddle,” says researcher Charalampos Tzoulis. He has lead the study together with researcher Kristoffer Haugarvoll at the same department.
One step further
Tzoulis says that the researchers have to do follow-up studies on the diabetes medicine to fully understand why it protects against Parkinson´s disease. “If we understand the mechanisms behind the protection, then we have a chance to develop a new treatment,” Tzoulis says.
Influence the cell´s powerhouse
The researchers believe that the diabetes medicines, containing so-called glitazones, are influencing the cells to produce more mitochondria. Mitochondria are the powerhouse of the cells, transforming nutrients that the cells need to work. Tzoulis´research group has previously shown that the production of mitochondria decreases during Parkinson´s.
100 million prescriptions
To see the connection between diabetes and Parkinson´s, the researchers analysed and compared data from the Norwegian Prescription Data Base. The database has stored information on all use of prescription the last 10 years and contains data on more than 100 million prescriptions.
http://www.uib.no/en/med/110489/diabetes-medicine-reduces-parkinson’s-risk
Nel mirtillo un'esplosione di sostanze benefiche per la salute
Che il mirtillo coltivato facesse bene alla salute già si sapeva, è noto infatti essere una straordinaria fonte di composti bioattivi, le antocianine. Tuttavia nei laboratori dell'Istituto Agrario di San Michele all'Adige si è scoperto che questi piccoli frutti contengono altre sostanze molto preziose: i flavonoli glicosidi, in particolare la quercetina, una classe di composti naturali noti per le loro proprietà antiossidanti, anticancerogene e di protezione dalle malattie coronariche.
Lo studio, durato quattro anni e finanziato dalla Provincia autonoma di Trento, è stato pubblicato sulla rivista scientifica americana Journal of food composition and analysis. L'articolo firmato da Urska Vrhovsek, Domenico Masuero, Luisa Palmieri e Fulvio Mattivi riguarda appunto l'identificazione e la quantificazione dei flavonoli glicosidi nelle differenti coltivazioni di mirtillo.
A brain-system that builds confidence in what we see, hear and touch
Behavioral scientists and psychologists use the term “metacognition” to describe our ability to access, report and regulate our own mental states: “thinking about thinking”, “knowing about knowing” “being aware about being aware”, are all higher-order cognitive skills that fit this category. Specifically, metacognition enables the brain to compute a degree of confidence when we perceive events from the external world, such as a sound, light, or touch. The accuracy of confidence estimates is crucial in daily life, for instance when hearing a baby crying, or smelling a gas leak. Confidence estimates also need to combine input from multiple senses simultaneously, for instance when buying a violin based on how it sounds, feels, and looks. From a neuroscience point of view, the way metacognition operates in different senses, and for combination of senses is still a mystery: Does metacognition use the same rules for visual, auditory, or tactile stimuli, or does it use different components of each of sensory domains? The first of these two ideas – i.e. the “common rules” – is known as “supramodality” and it has proven controversial among neuroscientists.
Discovery of a New Genetic Syndrome which Predisposes the Body to Cancer
Jordi Surrallés
A new syndrome caused by biallelic mutations - those produced in both gene copies inherited from the mother and father - in the FANCM gene predisposes the body to the appearance of tumours and causes rejection to chemotherapy treatments. Contrary to what scientists believed, the gene does not cause Fanconi anaemia. Researchers recommend modifying the clinical monitoring of patients with these mutations. A research led by Jordi Surrallés, professor of the Department of Genetics and Microbiology at the Universitat Autònoma de Barcelona, director of the Genetics Unit at the Hospital de la Santa Creu i Sant Pau and lead researcher at the Centre for Biomedical Network Research on Rare Diseases (CIBERER), has identified a new genetic syndrome caused by mutations in both copies of the FANCM gene, also known as biallelic mutations. The results, published in Genetics in Medicine, the official journal of the American College of Medical Genetics and part of the Nature group, suggest that these mutations predispose the body to early formations of tumours and chemotherapy toxicity.
NEL QUARTIERE COPPEDE’ NASCE UN “FIORE” !!!!!!!!!!!!!!!!!!
Palazzo in Via Ticino Oggi
Nuovo Progetto
Si tratta di un “fiore” specie ‘palazzina’, tipo balconatissima, colore bianca candida e rossa che si posizionerà al posto di un edificio esistente dei primi del novecento, ex educandato per studentesse gestito da suore Ancelle del Divino Cuore, che sarà demolito.
Il progetto della nuova palazzine è dell’arch. Alessandro Ridolfi attuale presidente dell’Ordine degli architetti e paesaggisti di Roma e provincia . I cittadini del II Municipio dopo aver scoperto cosa accadeva dietro il tendone bianco che invade anche una parte di via Ticino, sono rimasti basiti, increduli e molto preoccupati di ciò che sta per accadere ma anche del futuro del proprio territorio. Ma come, Roma non è la citta che ha il più avanzato P.R.G. (piano regolatore generale) del mondo avendo riconosciuto un valore storico non solo alla città entro le Mura Aureliane ma anche a tutti quegli edifici e tessuti che per qualità e storia vanno tutelati?
Roma non è la citta in cui non si muove foglia che sovrintendenza non voglia? Allora ci chiediamo: come è stato possibile che tutti gli enti preposti al controllo dell’edificazione abbiano consentito ad una operazione immobiliare del genere? Tutto ciò per realizzare 7 appartamenti lussuosi, 15 posti auto e 7 cantine.
Il quartiere Coppedè non è solo Piazza Mincio, ma anche il tessuto edilizio che si dipana lungo le strade al suo intorno con edifici dei primi del novecento. Non siamo integralisti, non siamo contro una sana politica di rigenerazione urbana, ma siamo contro questo tipo di intervento privo di cultura dei luoghi e di sensibilità paesaggistica, anche la città ha i suoi paesaggi da difendere. Speriamo che qualcuno intervenga e si possa fare qualcosa.
Rainbow colors reveal cell history: Uncovering β-cell heterogeneity by tracing developmental origins
Dr. Nikolay Ninov, group leader at the DFG research center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence at the TU Dresden, and Paul Langerhans Institute Dresden (PLID), and his group developed a system called “Beta-bow”, which allows the history of β-cells to be traced by genetic bar-coding and multicolor imaging. The results of this study are now published in the scientific journal Nature Communications.
Tracing the history of individual cells in the developing organism can reveal functional differences among seemingly uniform cells. This knowledge is important for defining the characteristics of highly regenerative cells in order to target them for cellular therapies, as well as to prevent the formation of unfit cells, which compromise the overall health of the organism. The study introduced here presents a new method for tracing the history of β-cells, which perform the essential function of secreting insulin in response to glucose. The authors traced β-cells with regards to their proliferation, function and time of differentiation in the zebrafish. The study shows that β-cells with different developmental histories co-exist together, which leads to the formation of dynamic sub-populations that differ in their potential for undergoing proliferation and performing functional tasks. The study also reveals the onset of β-cell function in zebrafish, which opens new avenues to investigate how β-cells acquire a functional state using this powerful genetic model.
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